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Insights from the structure of a smallpox virus topoisomerase-DNA transition state mimic
Poxviruses encode their own type IB topoisomerases (TopIBs) which release superhelical tension generated by replication and transcription of their genomes. To investigate the reaction catalyzed viral TopIBs, we have determined the structure of a variola virus topoisomerase-DNA complex trapped as a v...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822398/ https://ncbi.nlm.nih.gov/pubmed/20152159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.10.020 |
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