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Influence of Substrate Complexity on the Diastereoselective Formation of Spiroiminodihydantoin and Guanidinohydantoin from Chromate Oxidation

Chromate is a human carcinogen with a poorly defined mechanism of DNA damage. In vitro and prokaryotic studies have shown that DNA damage may occur via the formation of the hydantoin lesions guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) from further oxidation of 8-oxo-7,8-dihydroguanine (8o...

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書誌詳細
主要な著者: Gremaud, Julia N., Martin, Brooke D., Sugden, Kent D.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821960/
https://ncbi.nlm.nih.gov/pubmed/20014751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900362r
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