RASSF1A Elicits Apoptosis through an MST2 Pathway Directing Proapoptotic Transcription by the p73 Tumor Suppressor Protein

RASSF1A is a tumor suppressor gene that is epigenetically silenced in a wide variety of sporadic human malignancies. Expression of alternative RASSF1 isoforms cannot substitute for RASSF1A-promoted cell-cycle arrest and apoptosis. Apoptosis can be driven by either activating Bax or by activation of...

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Main Authors: Matallanas, David, Romano, David, Yee, Karen, Meissl, Katrin, Kucerova, Lucia, Piazzolla, Daniela, Baccarini, Manuela, Vass, J. Keith, Kolch, Walter, O’Neill, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821687/
https://ncbi.nlm.nih.gov/pubmed/17889669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.08.008
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