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The contribution of plasmid design and release to in vivo gene expression following delivery from cationic polymer modified scaffolds

Tissue engineering scaffolds capable of gene delivery can provide a structure that supports tissue formation while also inducing the expression of inductive factors. Sustained release strategies are hypothesized to maintain elevated plasmid concentrations locally that can enhance gene transfer. In t...

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Hlavní autoři: Avilés, Misael O., Lin, Chia-Hsuan, Zelivyanskaya, Marina, Graham, John G., Boehler, Ryan M., Messersmith, Phillip B., Shea, Lonnie D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821673/
https://ncbi.nlm.nih.gov/pubmed/19892398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2009.10.035
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