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The contribution of plasmid design and release to in vivo gene expression following delivery from cationic polymer modified scaffolds

Tissue engineering scaffolds capable of gene delivery can provide a structure that supports tissue formation while also inducing the expression of inductive factors. Sustained release strategies are hypothesized to maintain elevated plasmid concentrations locally that can enhance gene transfer. In t...

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Библиографические подробности
Главные авторы: Avilés, Misael O., Lin, Chia-Hsuan, Zelivyanskaya, Marina, Graham, John G., Boehler, Ryan M., Messersmith, Phillip B., Shea, Lonnie D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821673/
https://ncbi.nlm.nih.gov/pubmed/19892398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2009.10.035
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