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The contribution of plasmid design and release to in vivo gene expression following delivery from cationic polymer modified scaffolds

Tissue engineering scaffolds capable of gene delivery can provide a structure that supports tissue formation while also inducing the expression of inductive factors. Sustained release strategies are hypothesized to maintain elevated plasmid concentrations locally that can enhance gene transfer. In t...

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Autores principales: Avilés, Misael O., Lin, Chia-Hsuan, Zelivyanskaya, Marina, Graham, John G., Boehler, Ryan M., Messersmith, Phillip B., Shea, Lonnie D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821673/
https://ncbi.nlm.nih.gov/pubmed/19892398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2009.10.035
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