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DFT Studies of the Ring Opening Mechanism of SB-3CT, a Potent Inhibitor of Matrix Metalloproteinase 2

[Image: see text] SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition, by a thiirane-opening mechanism, of the MMP2 and MMP9 zinc metalloproteases. The deprotonation mechanism for thiirane opening of SB-3CT and for the opening of its oxirane analog, both relevant to the inhi...

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Bibliografiske detaljer
Main Authors: Tao, Peng, Fisher, Jed F., Mobashery, Shahriar, Bernhard Schlegel, H.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821186/
https://ncbi.nlm.nih.gov/pubmed/19445474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol9008393
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