Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential.

Anoxia of the heart causes failure of contraction before any irreversible injury occurs; the mechanism by which anoxia blocks cardiac excitation-contraction coupling is unknown. Studies in whole muscle are confounded by heterogeneity; however, achieving the low oxygen tensions required to study anox...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Stern, M D, Silverman, H S, Houser, S R, Josephson, R A, Capogrossi, M C, Nichols, C G, Lederer, W J, Lakatta, E G
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1988
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Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282097/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3413129/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.18.6954
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