Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential.

Anoxia of the heart causes failure of contraction before any irreversible injury occurs; the mechanism by which anoxia blocks cardiac excitation-contraction coupling is unknown. Studies in whole muscle are confounded by heterogeneity; however, achieving the low oxygen tensions required to study anox...

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Bibliographic Details
Main Authors: Stern, M D, Silverman, H S, Houser, S R, Josephson, R A, Capogrossi, M C, Nichols, C G, Lederer, W J, Lakatta, E G
Format: Artigo
Language:Inglês
Published: 1988
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC282097/
https://ncbi.nlm.nih.gov/pubmed/3413129
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