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A Human Cytomegalovirus gO-Null Mutant Fails To Incorporate gH/gL into the Virion Envelope and Is Unable To Enter Fibroblasts and Epithelial and Endothelial Cells

Human cytomegalovirus (HCMV) depends upon a five-protein complex, gH/gL/UL128-131, to enter epithelial and endothelial cells. A separate HCMV gH/gL-containing complex, gH/gL/gO, has been described. Our prevailing model is that gH/gL/UL128-131 is required for entry into biologically important epithel...

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Hlavní autoři: Wille, Paul T., Knoche, Amber J., Nelson, Jay A., Jarvis, Michael A., Johnson, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820920/
https://ncbi.nlm.nih.gov/pubmed/20032184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02249-09
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