Brain-Derived Neurotrophic Factor and Epidermal Growth Factor Activate Neuronal m-Calpain via Mitogen-Activated Protein Kinase-Dependent Phosphorylation

Calpain is a calcium-dependent protease that plays a significant role in synaptic plasticity, cell motility, and neurodegeneration. Two major calpain isoforms are present in brain, with μ-calpain (calpain1) requiring micromolar calcium concentrations for activation and m-calpain (calpain2) needing m...

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Autors principals: Zadran, Sohila, Jourdi, Hussam, Rostamiani, Karoline, Qin, Qingyu, Bi, Xiaoning, Baudry, Michel
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820881/
https://ncbi.nlm.nih.gov/pubmed/20089917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5120-09.2010
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