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Brain-Derived Neurotrophic Factor and Epidermal Growth Factor Activate Neuronal m-Calpain via Mitogen-Activated Protein Kinase-Dependent Phosphorylation
Calpain is a calcium-dependent protease that plays a significant role in synaptic plasticity, cell motility, and neurodegeneration. Two major calpain isoforms are present in brain, with μ-calpain (calpain1) requiring micromolar calcium concentrations for activation and m-calpain (calpain2) needing m...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820881/ https://ncbi.nlm.nih.gov/pubmed/20089917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5120-09.2010 |
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