Azadirachtin Interacts with the Tumor Necrosis Factor (TNF) Binding Domain of Its Receptors and Inhibits TNF-induced Biological Responses

The role of azadirachtin, an active component of a medicinal plant Neem (Azadirachta indica), on TNF-induced cell signaling in human cell lines was investigated. Azadirachtin blocks TNF-induced activation of nuclear factor κB (NF-κB) and also expression of NF-κB-dependent genes such as adhesion mole...

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Hlavní autoři: Thoh, Maikho, Kumar, Pankaj, Nagarajaram, Hampathalu A., Manna, Sunil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820814/
https://ncbi.nlm.nih.gov/pubmed/20018848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065847
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