Involvement of the Spliceosomal U4 Small Nuclear RNA in Heterochromatic Gene Silencing at Fission Yeast Centromeres

prp13-1 is one of the mutants isolated in a screen for defective pre-mRNA splicing at a nonpermissive temperature in fission yeast Schizosaccharomyces pombe. We cloned the prp13(+) gene and found that it encodes U4 small nuclear RNA (snRNA) involved in the assembly of the spliceosome. The prp13-1 mu...

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Bibliographic Details
Main Authors: Chinen, Madoka, Morita, Misato, Fukumura, Kazuhiro, Tani, Tokio
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820790/
https://ncbi.nlm.nih.gov/pubmed/20018856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074393
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