A DDX5 S480A Polymorphism Is Associated with Increased Transcription of Fibrogenic Genes in Hepatic Stellate Cells

We recently identified a missense single nucleotide polymorphism (SNP) in DDX5 (rs1140409, p.S480A) that enhances the risk of developing cirrhosis. DDX5 is an ATP-dependent RNA helicase and transcriptional modulator. We hypothesized that the activity of DDX5 in regulating fibrogenic gene transcripti...

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Main Authors: Guo, Jinsheng, Hong, Feng, Loke, Johnny, Yea, Steven, Lim, Chooi Ling, Lee, Ursula, Mann, Derek A., Walsh, Martin J., Sninsky, John J., Friedman, Scott L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820771/
https://ncbi.nlm.nih.gov/pubmed/20022962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.035295
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