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Regulation of Insulin Receptor Substrate 1 (IRS-1)/AKT Kinase-mediated Insulin Signaling by O-Linked β-N-Acetylglucosamine in 3T3-L1 Adipocytes

Increased O-linked β-N-acetylglucosamine (O-GlcNAc) is associated with insulin resistance in muscle and adipocytes. Upon insulin treatment of insulin-responsive adipocytes, O-GlcNAcylation of several proteins is increased. Key insulin signaling proteins, including IRS-1, IRS-2, and PDK1, are substra...

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Detalhes bibliográficos
Main Authors: Whelan, Stephen A., Dias, Wagner B., Thiruneelakantapillai, Lakshmanan, Lane, M. Daniel, Hart, Gerald W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820748/
https://ncbi.nlm.nih.gov/pubmed/20018868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077818
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