Inhibition of AcpA Phosphatase Activity with Ascorbate Attenuates Francisella tularensis Intramacrophage Survival

Acid phosphatase activity in the highly infectious intracellular pathogen Francisella tularensis is directly related with the ability of these bacteria to survive inside host cells. Pharmacological inactivation of acid phosphatases could potentially help in the treatment of tularemia or even be util...

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Autori principali: McRae, Steven, Pagliai, Fernando A., Mohapatra, Nrusingh P., Gener, Alejandro, Abdelgeliel Mahmou, Asma Sayed, Gunn, John S., Lorca, Graciela L., Gonzalez, Claudio F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820744/
https://ncbi.nlm.nih.gov/pubmed/20028980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039511
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