Inhibition of AcpA Phosphatase Activity with Ascorbate Attenuates Francisella tularensis Intramacrophage Survival

Acid phosphatase activity in the highly infectious intracellular pathogen Francisella tularensis is directly related with the ability of these bacteria to survive inside host cells. Pharmacological inactivation of acid phosphatases could potentially help in the treatment of tularemia or even be util...

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Autors principals: McRae, Steven, Pagliai, Fernando A., Mohapatra, Nrusingh P., Gener, Alejandro, Abdelgeliel Mahmou, Asma Sayed, Gunn, John S., Lorca, Graciela L., Gonzalez, Claudio F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820744/
https://ncbi.nlm.nih.gov/pubmed/20028980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039511
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