Inhibition of AcpA Phosphatase Activity with Ascorbate Attenuates Francisella tularensis Intramacrophage Survival

Acid phosphatase activity in the highly infectious intracellular pathogen Francisella tularensis is directly related with the ability of these bacteria to survive inside host cells. Pharmacological inactivation of acid phosphatases could potentially help in the treatment of tularemia or even be util...

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Bibliografiske detaljer
Main Authors: McRae, Steven, Pagliai, Fernando A., Mohapatra, Nrusingh P., Gener, Alejandro, Abdelgeliel Mahmou, Asma Sayed, Gunn, John S., Lorca, Graciela L., Gonzalez, Claudio F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820744/
https://ncbi.nlm.nih.gov/pubmed/20028980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039511
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