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Mechanistic Characterization and Molecular Modeling of Hepatitis B Virus Polymerase Resistance to Entecavir

BACKGROUND: Entecavir (ETV) is a deoxyguanosine analog competitive inhibitor of hepatitis B virus (HBV) polymerase that exhibits delayed chain termination of HBV DNA. A high barrier to entecavir-resistance (ETVr) is observed clinically, likely due to its potency and a requirement for multiple resist...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Walsh, Ann W., Langley, David R., Colonno, Richard J., Tenney, Daniel J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2010
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820545/
https://ncbi.nlm.nih.gov/pubmed/20169198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009195
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