Variable viral clearance despite adequate ganciclovir plasma levels during valganciclovir treatment for cytomegalovirus disease in D+/R- transplant recipients

BACKGROUND: Valganciclovir, the oral prodrug of ganciclovir, has been demonstrated equivalent to iv ganciclovir for CMV disease treatment in solid organ transplant recipients. Variability in ganciclovir exposure achieved with valganciclovir could be implicated as a contributing factor for explaining...

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Bibliographic Details
Main Authors: Perrottet, Nancy, Manuel, Oriol, Lamoth, Frédéric, Venetz, Jean-Pierre, Sahli, Roland, Decosterd, Laurent A, Buclin, Thierry, Pascual, Manuel, Meylan, Pascal
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820479/
https://ncbi.nlm.nih.gov/pubmed/20053269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-10-2
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