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Ascorbate inhibition of angiogenesis in aortic rings ex vivo and subcutaneous Matrigel plugs in vivo

BACKGROUND: Angiogenesis is critical to tumor growth and is therefore a potential target for cancer therapy. As many current inhibitors of angiogenesis exhibit host toxicity, natural alternatives are needed. At millimolar concentrations, ascorbate (vitamin C) inhibits migration and tubule formation...

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Autors principals: Mikirova, Nina A, Casciari, Joseph J, Riordan, Neil H
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820478/
https://ncbi.nlm.nih.gov/pubmed/20150992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2384-2-2
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