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Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies

Bone mineral density (BMD), a diagnostic parameter for osteoporosis and a clinical predictor of fracture, is a polygenic trait with high heritability. To identify genetic variants that influence BMD in different ethnic groups, we performed a genome-wide association study (GWAS) on 800 unrelated Sout...

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Detalhes bibliográficos
Main Authors: Kung, Annie W.C., Xiao, Su-Mei, Cherny, Stacey, Li, Gloria H.Y., Gao, Yi, Tso, Gloria, Lau, Kam S., Luk, Keith D.K., Liu, Jian-min, Cui, Bin, Zhang, Min-Jia, Zhang, Zhen-lin, He, Jin-wei, Yue, Hua, Xia, Wia-bo, Luo, Lian-mei, He, Shu-li, Kiel, Douglas P., Karasik, David, Hsu, Yi-Hsiang, Cupples, L. Adrienne, Demissie, Serkalem, Styrkarsdottir, Unnur, Halldorsson, Bjarni V., Sigurdsson, Gunnar, Thorsteinsdottir, Unnur, Stefansson, Kari, Richards, J. Brent, Zhai, Guangju, Soranzo, Nicole, Valdes, Ana, Spector, Tim D., Sham, Pak C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820171/
https://ncbi.nlm.nih.gov/pubmed/20096396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2009.12.014
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