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7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

Glycine markedly potentiates N-methyl-D-aspartate (N-Me-D-Asp) responses in mammalian neurons by an action at a modulatory site on the N-Me-D-Asp receptor-ionophore complex. Here we present evidence that 7-chlorokynurenic acid (7-Cl KYNA) inhibits N-Me-D-Asp responses by a selective antagonism of gl...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kemp, J A, Foster, A C, Leeson, P D, Priestley, T, Tridgett, R, Iversen, L L, Woodruff, G N
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282010/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2842779/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.17.6547
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