Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro.

Familial hypercholesterolemia is caused by a genetic deficiency of the low density lipoprotein (LDL) receptor. The Watanabe heritable hyperlipidemic (WHHL) rabbit, which is also defective in LDL receptor activity, provides an excellent animal model of homozygous familial hypercholesterolemia. As a s...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Miyanohara, A, Sharkey, M F, Witztum, J L, Steinberg, D, Friedmann, T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2842777/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.17.6538
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