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Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex
Histone deacetylase (HDAC) inhibitors are in clinical development for several diseases, including cancers and neurodegenerative disorders. HDACs1 and 2 are among the targets of these inhibitors and are part of multisubunit protein complexes. HDAC inhibitors (HDACi) block the activity of HDACs by che...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819981/ https://ncbi.nlm.nih.gov/pubmed/20142042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.12.010 |
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