Integration of In Vivo Genotoxicity and Short-term Carcinogenicity Assays Using F344 gpt Delta Transgenic Rats: In Vivo Mutagenicity of 2,4-Diaminotoluene and 2,6-Diaminotoluene Structural Isomers

An important trend in current toxicology is the replacement, reduction, and refinement of the use of experimental animals (the 3R principle). We propose a model in which in vivo genotoxicity and short-term carcinogenicity assays are integrated with F344 gpt delta transgenic rats. Using this model, t...

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Detalhes bibliográficos
Main Authors: Toyoda-Hokaiwado, Naomi, Inoue, Tomoki, Masumura, Kenichi, Hayashi, Hiroyuki, Kawamura, Yuji, Kurata, Yasushi, Takamune, Makiko, Yamada, Masami, Sanada, Hisakazu, Umemura, Takashi, Nishikawa, Akiyoshi, Nohmi, Takehiko
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Genetic Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819973/
https://ncbi.nlm.nih.gov/pubmed/20026473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp306
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