17β-Estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts

AIMS: Female sex and sex hormones contribute to cardiac remodelling. 17β-estradiol (E2) is involved in the modulation of extracellular matrix composition and function. Here, we analysed the effect of E2 on matrix metalloproteinase (MMP)-2 gene expression and studied the underlying molecular mechanis...

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Bibliographic Details
Main Authors: Mahmoodzadeh, Shokoufeh, Dworatzek, Elke, Fritschka, Stephan, Pham, Thi Hang, Regitz-Zagrosek, Vera
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819834/
https://ncbi.nlm.nih.gov/pubmed/19861308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp350
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