Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anti-cancer and radio-sensitizing target

PURPOSE: SAG (Sensitive to Apoptosis Gene, also known as RBX2 or ROC2) was originally cloned as a redox inducible antioxidant protein and was later characterized as a RING component of SCF E3 ubiquitin ligases. SAG overexpression inhibits apoptosis induced by many stimuli both in vitro and in vivo....

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Hlavní autoři: Jia, Lijun, Yang, Jie, Hao, Xinbao, Zheng, Min, He, Hongbin, Xiong, Xiufang, Xu, Liang, Sun, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819752/
https://ncbi.nlm.nih.gov/pubmed/20103673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1592
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