Proteasome Inhibition in Human Breast Cancer Cells with High Catechol-O-methyltransferase Activity by Green tea polyphenol EGCG analogs

A pro-drug 8 of a synthetic analog 7 is more active in its anti-proliferative activity against human breast cancer MDA-MB-231 cells possessing high Catechol-O-methyltransferase (COMT) activity than the pro-drugs of EGCG and the analog 5. The higher activity of 8 is attributed to it not being a subst...

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Main Authors: Huo, Congde, Yang, Huanjie, Cindy Cui, Qiuzhi, Dou, Q. Ping, Chan, Tak Hang
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819655/
https://ncbi.nlm.nih.gov/pubmed/20045338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.034
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