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Design and Stereoselective Preparation of a New Class of Chiral Olefin Metathesis Catalysts and Application to Enantioselective Synthesis of Quebrachamine: Catalyst Development Inspired by Natural Product Synthesis

A total synthesis of the Aspidosperma alkaloid quebrachamine in racemic form is first described. A key catalytic ring-closing metathesis of an achiral triene is used to establish the all-carbon quaternary stereogenic center and the tetracyclic structure of the natural product; the catalytic transfor...

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מידע ביבליוגרפי
Main Authors: Sattely, Elizabeth S., Meek, Simon J., Malcolmson, Steven J., Schrock, Richard R., Hoveyda, Amir H.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819342/
https://ncbi.nlm.nih.gov/pubmed/19113867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8084934
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