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Initiation of DNA Strand Cleavage by 1,2,4-Benzotriazine 1,4-Dioxide Antitumor Agents: Mechanistic Insight from Studies of 3-Methyl-1,2,4-benzotriazine 1,4-Dioxide

The antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine, TPZ, 1) gains medicinal activity through its ability to selectively damage DNA in the hypoxic cells found inside solid tumors. This occurs via one-electron enzymatic reduction of TPZ to yield an oxygen-sensitive drug radical...

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Autori principali: Junnotula, Venkatraman, Sarkar, Ujjal, Sinha, Sarmistha, Gates, Kent S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819123/
https://ncbi.nlm.nih.gov/pubmed/19117394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8049645
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