Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase (AEP)

Ischemia and seizure cause excessive neuronal excitation that is associated with brain acidosis and neuronal cell death. However, the molecular mechanism of acidification-triggered neuronal injury is incompletely understood. Here, we show that Asparagine Endopeptidase (AEP) is activated under acidic...

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Detalhes bibliográficos
Main Authors: Liu, Zhixue, Jang, Sung-Wuk, Liu, Xia, Cheng, Dongmei, Peng, Junmin, Yepes, Maneul, Li, Xiao-jiang, Matthews, Steve, Watts, Colin, Asano, Masahide, Hara-Nishimura, Ikuko, Luo, Hongbo R., Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819101/
https://ncbi.nlm.nih.gov/pubmed/18374643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.02.017
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