Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase (AEP)

Ischemia and seizure cause excessive neuronal excitation that is associated with brain acidosis and neuronal cell death. However, the molecular mechanism of acidification-triggered neuronal injury is incompletely understood. Here, we show that Asparagine Endopeptidase (AEP) is activated under acidic...

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Библиографические подробности
Главные авторы: Liu, Zhixue, Jang, Sung-Wuk, Liu, Xia, Cheng, Dongmei, Peng, Junmin, Yepes, Maneul, Li, Xiao-jiang, Matthews, Steve, Watts, Colin, Asano, Masahide, Hara-Nishimura, Ikuko, Luo, Hongbo R., Ye, Keqiang
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819101/
https://ncbi.nlm.nih.gov/pubmed/18374643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.02.017
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