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Creation of a Zymogen
Cells produce proteases as inactive zymogens. Herein, we demonstrate that this tactic can extend beyond proteases. By linking the N- and C-termini of ribonuclease A, we obstruct the active site with the amino acid sequence recognized by plasmepsin II, a highly specific protease from Plasmodium falci...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819095/ https://ncbi.nlm.nih.gov/pubmed/12496934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsb884 |
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