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Creation of a Zymogen

Cells produce proteases as inactive zymogens. Herein, we demonstrate that this tactic can extend beyond proteases. By linking the N- and C-termini of ribonuclease A, we obstruct the active site with the amino acid sequence recognized by plasmepsin II, a highly specific protease from Plasmodium falci...

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Sonraí Bibleagrafaíochta
Main Authors: Plainkum, Parit, Fuchs, Stephen M., Wiyakrutta, Suthep, Raines, Ronald T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819095/
https://ncbi.nlm.nih.gov/pubmed/12496934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsb884
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