Developmentally regulated SMAD2 and SMAD3 utilization directs activin signalling outcomes

Activin is required for testis development. Activin signals via the phosphorylation and nuclear accumulation of SMAD2 and SMAD3. We present novel findings of developmentally regulated activin signalling leading to specific transcriptional outcomes in testicular Sertoli cells. In immature, proliferat...

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Autori principali: Itman, Catherine, Small, Chris, Griswold, Michael, Nagaraja, Ankur K., Matzuk, Martin M., Brown, Chester, Jans, David A., Loveland, Kate L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819023/
https://ncbi.nlm.nih.gov/pubmed/19517569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.21995
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