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Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition
We studied human cancer cell models in which we detected constitutive activation of ERK. A fraction of active ERK was found to be located in mitochondria in RWPE-2 cells, obtained by v-Ki-Ras transformation of the epithelial prostate RWPE-1 cell line; in metastatic prostate cancer DU145 cells; and i...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818893/ https://ncbi.nlm.nih.gov/pubmed/20080742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912742107 |
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