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R loops stimulate genetic instability of CTG·CAG repeats
Transcription stimulates the genetic instability of trinucleotide repeat sequences. However, the mechanisms leading to transcription-dependent repeat length variation are unclear. We demonstrate, using biochemical and genetic approaches, that the formation of stable RNA·DNA hybrids enhances the inst...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818888/ https://ncbi.nlm.nih.gov/pubmed/20080737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909740107 |
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