An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.
We have identified a protein present only in erythroid cells that binds to two adjacent sites within an enhancer region of the chicken beta-globin locus. Mutation of the sites, so that binding by the factor can no longer be detected in vitro, leads to a loss of enhancing ability, assayed by transien...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1988
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281888/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3413070/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.16.5976 |
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