Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivo

BACKGROUND: Oncolytic virotherapy is an attractive drug platform of cancer gene therapy, but efficacy and specificity are important prerequisites for success of such strategies. Previous studies determined that Apoptin is a p53 independent, bcl-2 insensitive apoptotic protein with the ability to spe...

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Detalhes bibliográficos
Main Authors: Xiao, Li, Yan, Liu, Zhongmei, Wen, Chang, Li, Huijun, Lu, Mingyao, Tian, Kuoshi, Jin, Lili, Sun, Pegn, Gao, Encheng, Yang, Xiaohong, Xu, Shifu, Kan, Zhuoyue, Wang, Yuhang, Wang, Ningyi, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818692/
https://ncbi.nlm.nih.gov/pubmed/20085660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-10
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