Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-D-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC)

High-throughput screening of 201,368 compounds revealed that 1-(3-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one (SID 7975595) inhibited RmlC a TB cell wall biosynthetic enzyme. SID 7975595 acts as a competitive inhibitor of the enzyme’s substrate and inhibits...

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Autors principals: Sivendran, Sharmila, Jones, Victoria, Sun, Dianqing, Wang, Yi, Grzegorzewicz, Anna E., Scherman, Michael S., Napper, Andrew D., McCammon, J. Andrew, Lee, Richard E., Diamond, Scott L., McNeil, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818544/
https://ncbi.nlm.nih.gov/pubmed/19969466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.11.033
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