In Vivo Pharmaco-Proteomic Analysis of Hydroxyurea Induced Changes in the Sickle Red Blood Cell Membrane Proteome

Hydroxyurea (HU) is an effective drug for the treatment of sickle cell disease (SCD). The main clinical benefit of HU is thought to derive from its capacity to increase fetal hemoglobin (HbF) production. However, other effects leading to clinical benefit, such as improved blood rheology, have been s...

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Main Authors: Ghatpande, Swati S., Choudhary, Pankaj K., Quinn, Charles T., Goodman, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818491/
https://ncbi.nlm.nih.gov/pubmed/19914412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jprot.2009.11.003
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