Sample sizes for brain atrophy outcomes in trials for secondary progressive multiple sclerosis

BACKGROUND: Progressive brain atrophy in multiple sclerosis (MS) may reflect neuroaxonal and myelin loss and MRI measures of brain tissue loss are used as outcome measures in MS treatment trials. This study investigated sample sizes required to demonstrate reduction of brain atrophy using three outc...

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Autori principali: Altmann, D R., Jasperse, B, Barkhof, F, Beckmann, K, Filippi, M, Kappos, L D., Molyneux, P, Polman, C H., Pozzilli, C, Thompson, A J., Wagner, K, Yousry, T A., Miller, D H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Academy of Neurology 2009
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818185/
https://ncbi.nlm.nih.gov/pubmed/19005170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/01.wnl.0000335765.55346.fc
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