A New Caspase-8 Isoform Caspase-8s Increased Sensitivity to Apoptosis in Jurkat Cells

Caspase-8 is a key initiator of death receptor-induced apoptosis. Here we report a novel short isoform of caspase-8 (caspase-8s), which encodes the first (Death Effector Domain) DED and part of the second DED, missing the C-terminal caspase domain. In vivo binding assays showed that transfected casp...

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Bibliographic Details
Main Authors: Xu, Zhifang, Tang, Kejing, Wang, Min, Rao, Qing, Liu, Bolin, Wang, Jianxiang
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817811/
https://ncbi.nlm.nih.gov/pubmed/20150972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/930462
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