ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2

BACKGROUND: Fibrillins 1 (FBN1) and 2 (FBN2) are components of microfibrils, microfilaments that are present in many connective tissues, either alone or in association with elastin. Marfan's syndrome and congenital contractural arachnodactyly (CCA) result from dominant mutations in the genes FB...

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Main Authors: Miller, Gaynor, Neilan, Monica, Chia, Ruth, Gheryani, Nabeia, Holt, Natalie, Charbit, Annabelle, Wells, Sara, Tucci, Valter, Lalanne, Zuzanne, Denny, Paul, Fisher, Elizabeth M. C., Cheeseman, Michael, Askew, Graham N., Dear, T. Neil
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817753/
https://ncbi.nlm.nih.gov/pubmed/20161761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009137
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