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EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII
Combined deficiency of factor V and factor VIII (F5F8D) is a bleeding disorder caused by mutations in either LMAN1 or MCFD2. LMAN1 (ERGIC-53) and MCFD2 form a Ca(2+)-dependent cargo receptor that cycles between the endoplasmic reticulum (ER) and the ER-Golgi intermediate compartment for efficient tr...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2817634/ https://ncbi.nlm.nih.gov/pubmed/20007547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-241877 |
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