Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.
A single mutation altering the transmembrane domain of the receptor-like p185 protein encoded by the rat neu gene converts the normal neu gene into a potent oncogene. The biochemical consequences of this mutation were studied by examining phosphorylation of the normal and transforming p185 molecules...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1988
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281763/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2899890/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.15.5394 |
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