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Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

A single mutation altering the transmembrane domain of the receptor-like p185 protein encoded by the rat neu gene converts the normal neu gene into a potent oncogene. The biochemical consequences of this mutation were studied by examining phosphorylation of the normal and transforming p185 molecules...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bargmann, C I, Weinberg, R A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1988
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281763/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2899890/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.15.5394
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