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The role of calcium-independent phospholipase A(2) in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart

Cardiolipin (CL) is an essential phospholipid component of the inner mitochondrial membrane. In the mammalian heart, the functional form of CL is tetralinoleoyl CL [(18:2)(4)CL]. A decrease in (18:2)(4)CL content, which is believed to negatively impact mitochondrial energetics, occurs in heart failu...

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Autori principali: Zachman, Derek K., Chicco, Adam J., McCune, Sylvia A., Murphy, Robert C., Moore, Russell L., Sparagna, Genevieve C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817582/
https://ncbi.nlm.nih.gov/pubmed/19741254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M000646
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