Cisplatin-induced expression of Gb3 enables verotoxin-1 treatment of cisplatin resistance in malignant pleural mesothelioma cells

BACKGROUND: A major problem with cisplatin treatment is the development of acquired-drug resistance of the tumour cells. Verotoxin-1 (VT-1) exerts its cytotoxicity by targeting the membrane glycolipid globotriasosylceramide (Gb3), a molecule associated with drug resistance. Cisplatin- and VT-1-induc...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Johansson, D, Andersson, C, Moharer, J, Johansson, A, Behnam-Motlagh, P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Molecular Diagnostics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816648/
https://ncbi.nlm.nih.gov/pubmed/20010943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605467
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki