A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons

Familial neurohypophyseal diabetes insipidus (FNDI) is an autosomal dominant disorder caused by mutations in the arginine vasopressin (AVP) precursor. The pathogenesis of FNDI is proposed to involve mutant protein–induced loss of AVP-producing neurons. We established murine knock-in models of two di...

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Auteurs principaux: Russell, Theron A., Ito, Masafumi, Ito, Mika, Yu, Richard N., Martinson, Fred A., Weiss, Jeffrey, Jameson, J. Larry
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2003
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC281642/
https://ncbi.nlm.nih.gov/pubmed/14660745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318616
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