Association Between Disease-Free Survival and Overall Survival When Survival Is Prolonged After Recurrence in Patients Receiving Cytotoxic Adjuvant Therapy for Colon Cancer: Simulations Based on the 20,800 Patient ACCENT Data Set

PURPOSE: We previously validated disease-free survival (DFS) as a surrogate for overall survival (OS) in fluorouracil-based adjuvant colon cancer clinical trials. New therapies have extended survival after recurrence from 1 to approximately 2 years. We examined the possible impact of this improvemen...

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Autores principales: de Gramont, Aimery, Hubbard, Joleen, Shi, Qian, O'Connell, Michael J., Buyse, Marc, Benedetti, Jacqueline, Bot, Brian, O'Callaghan, Chris, Yothers, Greg, Goldberg, Richard M., Blanke, Charles D., Benson, Al, Deng, Qiqi, Alberts, Steven R., Andre, Thierry, Wolmark, Norman, Grothey, Axel, Sargent, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Clinical Oncology 2010
Materias:
Original Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815708/
https://ncbi.nlm.nih.gov/pubmed/20008641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.23.1407
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