Association Between Disease-Free Survival and Overall Survival When Survival Is Prolonged After Recurrence in Patients Receiving Cytotoxic Adjuvant Therapy for Colon Cancer: Simulations Based on the 20,800 Patient ACCENT Data Set

PURPOSE: We previously validated disease-free survival (DFS) as a surrogate for overall survival (OS) in fluorouracil-based adjuvant colon cancer clinical trials. New therapies have extended survival after recurrence from 1 to approximately 2 years. We examined the possible impact of this improvemen...

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Detalhes bibliográficos
Main Authors: de Gramont, Aimery, Hubbard, Joleen, Shi, Qian, O'Connell, Michael J., Buyse, Marc, Benedetti, Jacqueline, Bot, Brian, O'Callaghan, Chris, Yothers, Greg, Goldberg, Richard M., Blanke, Charles D., Benson, Al, Deng, Qiqi, Alberts, Steven R., Andre, Thierry, Wolmark, Norman, Grothey, Axel, Sargent, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2010
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815708/
https://ncbi.nlm.nih.gov/pubmed/20008641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.23.1407
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