Molecular modeling of the bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase and predictions of structural effects of mutations associated with HIBM and sialuria

The bifunctional enzyme UDP-GlcNAc 2-epimerase/ ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneuraminic acid (sialic acid). GNE/MNK is feedback inhibited by binding of the downstream product, CMP-sialic acid i...

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Bibliographic Details
Main Authors: Kurochkina, Natalya, Yardeni, Tal, Huizing, Marjan
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815652/
https://ncbi.nlm.nih.gov/pubmed/19917666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwp176
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